PlantImRecepV1, Main, Exploration, bibRecord, 000141

Human Umbilical Mesenchymal Stem Cells Display Therapeutic Potential in Rheumatoid Arthritis by Regulating Interactions Between Immunity and Gut Microbiota via the Aryl Hydrocarbon Receptor.

Identifieur interne : 000141 ( Main/Exploration ); précédent : 000140; suivant : 000142

Human Umbilical Mesenchymal Stem Cells Display Therapeutic Potential in Rheumatoid Arthritis by Regulating Interactions Between Immunity and Gut Microbiota via the Aryl Hydrocarbon Receptor.

Auteurs : Xiaoya Li [République populaire de Chine] ; Cheng Lu [République populaire de Chine] ; Danping Fan [République populaire de Chine] ; Xiangchen Lu [République populaire de Chine] ; Ya Xia [République populaire de Chine] ; Hongyan Zhao [République populaire de Chine] ; Huihui Xu [République populaire de Chine] ; Yongliang Zhu [États-Unis] ; Jingtao Li [République populaire de Chine] ; Honglin Liu [République populaire de Chine] ; Cheng Xiao [République populaire de Chine]

Source :

Frontiers in cell and developmental biology [ 2296-634X ] ; 2020.

RBID : pubmed:32232043

Abstract

Background

Rheumatoid arthritis (RA) is an autoimmune disease that may be associated with gut microbiota

Method

HUMSCs (1 × 10

Results

HUMSCs homed to the popliteal lymph node (PLN), mesenteric lymph node (MLN), ankle cartilage, and ileum mucosa in rats with CIA. The transplantation of HUMSCs reduced the pathology scores and the degree of bone damage in the ankles. The immune status of T regulatory cells (Tregs) and T helper (Th)17 cells and the gene expression levels of interleukin (IL)-10, transforming growth factor (TGF)-β

Conclusion

Our study demonstrates that HUMSCs play a therapeutic role in rats with CIA by regulating the interactions between host immunity and gut microbiota

DOI: 10.3389/fcell.2020.00131
PubMed: 32232043
PubMed Central: PMC7082776

Affiliations:

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 the Aryl Hydrocarbon Receptor.</title>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Human Umbilical Mesenchymal Stem Cells Display Therapeutic Potential in Rheumatoid Arthritis by Regulating Interactions Between Immunity and Gut Microbiota <i>via</i>
 the Aryl Hydrocarbon Receptor.</title>
<author><name sortKey="Li, Xiaoya" sort="Li, Xiaoya" uniqKey="Li X" first="Xiaoya" last="Li">Xiaoya Li</name>
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<affiliation wicri:level="3"><nlm:affiliation>Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China.</nlm:affiliation>
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<author><name sortKey="Fan, Danping" sort="Fan, Danping" uniqKey="Fan D" first="Danping" last="Fan">Danping Fan</name>
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<author><name sortKey="Lu, Xiangchen" sort="Lu, Xiangchen" uniqKey="Lu X" first="Xiangchen" last="Lu">Xiangchen Lu</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<placeName><settlement type="city">Pékin</settlement>
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<affiliation wicri:level="3"><nlm:affiliation>School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
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<author><name sortKey="Xia, Ya" sort="Xia, Ya" uniqKey="Xia Y" first="Ya" last="Xia">Ya Xia</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
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<author><name sortKey="Zhao, Hongyan" sort="Zhao, Hongyan" uniqKey="Zhao H" first="Hongyan" last="Zhao">Hongyan Zhao</name>
<affiliation wicri:level="3"><nlm:affiliation>Beijing Key Laboratory of Research of Chinese Medicine on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Key Laboratory of Research of Chinese Medicine on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xu, Huihui" sort="Xu, Huihui" uniqKey="Xu H" first="Huihui" last="Xu">Huihui Xu</name>
<affiliation wicri:level="3"><nlm:affiliation>Beijing Key Laboratory of Research of Chinese Medicine on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Beijing Key Laboratory of Research of Chinese Medicine on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
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<author><name sortKey="Zhu, Yongliang" sort="Zhu, Yongliang" uniqKey="Zhu Y" first="Yongliang" last="Zhu">Yongliang Zhu</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA, United States.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
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<author><name sortKey="Li, Jingtao" sort="Li, Jingtao" uniqKey="Li J" first="Jingtao" last="Li">Jingtao Li</name>
<affiliation wicri:level="3"><nlm:affiliation>Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Gastroenterology, China-Japan Friendship Hospital, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Honglin" sort="Liu, Honglin" uniqKey="Liu H" first="Honglin" last="Liu">Honglin Liu</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
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<author><name sortKey="Xiao, Cheng" sort="Xiao, Cheng" uniqKey="Xiao C" first="Cheng" last="Xiao">Cheng Xiao</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Emergency, China-Japan Friendship Hospital, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
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<affiliation wicri:level="3"><nlm:affiliation>Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:affiliation>Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Frontiers in cell and developmental biology</title>
<idno type="ISSN">2296-634X</idno>
<imprint><date when="2020" type="published">2020</date>
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<front><div type="abstract" xml:lang="en"><p><b>Background</b>
</p>
<p>Rheumatoid arthritis (RA) is an autoimmune disease that may be associated with gut microbiota </p>
</div>
<div type="abstract" xml:lang="en"><p><b>Method</b>
</p>
<p>HUMSCs (1 × 10</p>
</div>
<div type="abstract" xml:lang="en"><p><b>Results</b>
</p>
<p>HUMSCs homed to the popliteal lymph node (PLN), mesenteric lymph node (MLN), ankle cartilage, and ileum mucosa in rats with CIA. The transplantation of HUMSCs reduced the pathology scores and the degree of bone damage in the ankles. The immune status of T regulatory cells (Tregs) and T helper (Th)17 cells and the gene expression levels of interleukin (IL)-10, transforming growth factor (TGF)-β</p>
</div>
<div type="abstract" xml:lang="en"><p><b>Conclusion</b>
</p>
<p>Our study demonstrates that HUMSCs play a therapeutic role in rats with CIA by regulating the interactions between host immunity and gut microbiota </p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32232043</PMID>
<DateRevised><Year>2020</Year>
<Month>09</Month>
<Day>28</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">2296-634X</ISSN>
<JournalIssue CitedMedium="Print"><Volume>8</Volume>
<PubDate><Year>2020</Year>
</PubDate>
</JournalIssue>
<Title>Frontiers in cell and developmental biology</Title>
<ISOAbbreviation>Front Cell Dev Biol</ISOAbbreviation>
</Journal>
<ArticleTitle>Human Umbilical Mesenchymal Stem Cells Display Therapeutic Potential in Rheumatoid Arthritis by Regulating Interactions Between Immunity and Gut Microbiota <i>via</i>
 the Aryl Hydrocarbon Receptor.</ArticleTitle>
<Pagination><MedlinePgn>131</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.3389/fcell.2020.00131</ELocationID>
<Abstract><AbstractText Label="Background" NlmCategory="UNASSIGNED">Rheumatoid arthritis (RA) is an autoimmune disease that may be associated with gut microbiota <i>via</i>
 the aryl hydrocarbon receptor (AhR). Human umbilical mesenchymal stem cells (HUMSCs) have therapeutic potential against RA, but the underlying mechanism has not been fully elucidated. The purpose of this study was to explore the mechanism of action of HUMSCs in rats with collagen-induced arthritis (CIA).</AbstractText>
<AbstractText Label="Method" NlmCategory="UNASSIGNED">HUMSCs (1 × 10<sup>6</sup>
) were transplanted into each rat with CIA. The tissue localization of HUMSCs and the therapeutic effects in the ankles were assessed. The immune status and expression of immune-related genes and proteins in related lymphoid tissues were subsequently tested. Furthermore, the levels of immune-related factors in serum and the changes in gut microbiota in the ileum were detected, and the levels of indole and their derivatives in plasma and the levels of AhR in the ileum were evaluated.</AbstractText>
<AbstractText Label="Results" NlmCategory="UNASSIGNED">HUMSCs homed to the popliteal lymph node (PLN), mesenteric lymph node (MLN), ankle cartilage, and ileum mucosa in rats with CIA. The transplantation of HUMSCs reduced the pathology scores and the degree of bone damage in the ankles. The immune status of T regulatory cells (Tregs) and T helper (Th)17 cells and the gene expression levels of interleukin (IL)-10, transforming growth factor (TGF)-β<i>1</i>
, and IL-17A were altered in the PLN, which is the lymph tissue closest to the nidus, and the MLN, which is one of the gut-associated lymphoid tissues (GALTs). The proportion and function of B cells, Tregs, and Th17 cells were regulated in other GALTs, namely, Peyer's patches and the lamina propria. The gene expression of TGF-β<i>1</i>
 and IL-17A and protein expression of IL-10, TGF-β<i>1</i>
, IL-17A, IL-22, and immunoglobulin A (IgA) were modulated in the ileum, and the serum levels of IL-10, TGF-β1, IL-17A, IL-1β, and tumor necrosis factor (TNF)-α were regulated in the rats with CIA. The relative abundances of the genera <i>Bacteroides</i>
 and <i>Bacillus</i>
 were increased in the HUMSCs-treated rat with CIA; in addition, the levels of indole, indoleacetic acid, and indole-3-lactic acid were consistently upregulated, and this upregulation was accompanied by increases in AhR gene and protein expression.</AbstractText>
<AbstractText Label="Conclusion" NlmCategory="UNASSIGNED">Our study demonstrates that HUMSCs play a therapeutic role in rats with CIA by regulating the interactions between host immunity and gut microbiota <i>via</i>
 the AhR.</AbstractText>
<CopyrightInformation>Copyright © 2020 Li, Lu, Fan, Lu, Xia, Zhao, Xu, Zhu, Li, Liu and Xiao.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Xiaoya</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Department of Emergency, China-Japan Friendship Hospital, Beijing, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lu</LastName>
<ForeName>Cheng</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fan</LastName>
<ForeName>Danping</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lu</LastName>
<ForeName>Xiangchen</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xia</LastName>
<ForeName>Ya</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhao</LastName>
<ForeName>Hongyan</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Beijing Key Laboratory of Research of Chinese Medicine on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xu</LastName>
<ForeName>Huihui</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Beijing Key Laboratory of Research of Chinese Medicine on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhu</LastName>
<ForeName>Yongliang</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA, United States.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Jingtao</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Honglin</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xiao</LastName>
<ForeName>Cheng</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Emergency, China-Japan Friendship Hospital, Beijing, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>03</Month>
<Day>13</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Switzerland</Country>
<MedlineTA>Front Cell Dev Biol</MedlineTA>
<NlmUniqueID>101630250</NlmUniqueID>
<ISSNLinking>2296-634X</ISSNLinking>
</MedlineJournalInfo>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">aryl hydrocarbon receptor</Keyword>
<Keyword MajorTopicYN="N">gut microbiota</Keyword>
<Keyword MajorTopicYN="N">host immunity</Keyword>
<Keyword MajorTopicYN="N">human umbilical mesenchymal stem cells</Keyword>
<Keyword MajorTopicYN="N">rheumatoid arthritis</Keyword>
</KeywordList>
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<Month>12</Month>
<Day>12</Day>
</PubMedPubDate>
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<Month>02</Month>
<Day>14</Day>
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<Day>2</Day>
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<name sortKey="Xia, Ya" sort="Xia, Ya" uniqKey="Xia Y" first="Ya" last="Xia">Ya Xia</name>
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Human Umbilical Mesenchymal Stem Cells Display Therapeutic Potential in Rheumatoid Arthritis by Regulating Interactions Between Immunity and Gut Microbiota via the Aryl Hydrocarbon Receptor.

Human Umbilical Mesenchymal Stem Cells Display Therapeutic Potential in Rheumatoid Arthritis by Regulating Interactions Between Immunity and Gut Microbiota via the Aryl Hydrocarbon Receptor.

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